Hermann Einsele, MD, FRCP, of the University of Würzburg, Würzburg, Germany, and Heinz Ludwig, MD, of the Wilhelminen Cancer Research Institute, Wilhelminenspital, Vienna, Austria, talk on the latest developments in the field of multiple myeloma. Prof. Einsele discusses immunological strategies for myeloma treatment, such as antibody-drug conjugates, monoclonal antibodies and bispecific antibodies. Prof. Einsele also comments on the use of cellular therapies. This interview took place during the 18th International Myeloma Workshop (IMW 2021) congress.