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EHA 2026 | Practical strategies to better prevent and manage infections in multiple myeloma
Efstathios Kastritis, MD, University of Athens School of Medicine, Athens, Greece, discusses practical approaches to preventing and managing infections in patients with multiple myeloma. He reviews the importance of risk assessment, vaccination, antimicrobial prophylaxis, immunoglobulin replacement in selected patients, and early recognition and treatment of infections, particularly in those receiving bispecific antibody therapies. This interview took place at the 31st Congress of the European Hematology Association (EHA) in Stockholm, Sweden.
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Transcript
Infections remain a major problem for all patients with multiple myeloma, starting from those who are newly diagnosed and even worse for patients who have relapsed disease or refractory disease and have been exposed to many different types of therapy. For newly diagnosed patients, there are guidelines suggesting that for those especially at higher risk, antibiotic prophylaxis, careful evaluation for the risk of infections, vaccinations, self-protective measures like masks or hand hygiene are very important...
Infections remain a major problem for all patients with multiple myeloma, starting from those who are newly diagnosed and even worse for patients who have relapsed disease or refractory disease and have been exposed to many different types of therapy. For newly diagnosed patients, there are guidelines suggesting that for those especially at higher risk, antibiotic prophylaxis, careful evaluation for the risk of infections, vaccinations, self-protective measures like masks or hand hygiene are very important. For patients at very high risk and especially those with hypogammaglobulinemia it seems that the use of immunoglobulin supplementation can significantly reduce the risk of infections and this is more pronounced in patients treated with bispecific antibodies targeting BCMA in which the implementation of preventive use of supplemental immunoglobulin seems to reduce the infection rate by 50 to 80 percent. So these are the main measures. It is also very important for the patients, their caregivers and the physicians to recognize the infections and be very aggressive when they manage patients with a suspicion of infection.
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