Welcome to Measurable Residual Disease (MRD) Focus.
Explore the cutting-edge updates in MRD by disease type, including expert interviews from major international congresses, podcasts and e-learning.
MRD is the term used to describe a small number of cancer cells remaining in patients following treatment, which are below the level of routine morphological detection1,2. Even when a patient is in remission it is possible for them to be ‘MRD positive’. The level of MRD can, theoretically, be used as a prognostic indicator to determine treatment efficacy and to detect cancer recurrence. MRD status is now increasingly measured as an endpoint in clinical trials for haematological malignancies, with the goal of treatment being MRD negativity.
- Ossenkoppele G, Schuurhuis GJ. MRD in AML: time for redefinition of CR? Blood. 2013 Mar 21; 121(12): 2166-2168.
- Ravandi F, Walter RB, Freeman SD. Evaluating measurable residual disease in acute myeloid leukemia. Blood Adv. 2018 Jun 12; 2(11): 1356-1366.