Myeloproliferative Neoplasms

Myeloproliferative neoplasms (MPN) are clonal disorders leading to excessive production of mature blood cells. Classic MPN include polycythemia vera, essential thrombocythemia, primitive myelofibrosis and chronic myeloid leukemia.

MPN now also includes hypereosinophillic syndromes, mastocytosis, chronic neutrophil leukemia and chronic hemopathies. Several of the MPNs are due to genetic aberrations such as JAK2V617F and MPL variants, which has led to research focussing on targeted therapy in these areas.