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ASH 2023 | The prognostic value of peripheral blood MRD status following Elo-KRd in newly diagnosed myeloma

Benjamin Derman, MD, University of Chicago, Chicago, IL, explores the utility of next-generation sequencing (NGS) of peripheral blood (PB) samples as an alternative to bone marrow (BM) samples for assessing the measurable residual disease (MRD) status of patients with newly diagnosed multiple myeloma (MM) following 4 cycles of treatment with elotuzumab, carfilzomib, lenalidomide, and dexamethasone (Elo-KRd). The study found that MRD status in both BM and PB is a prognostic indicator, predicting outcomes such as progression-free survival (PFS) and overall survival (OS). This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.

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Consultancy: Janssen, COTA Healthcare
Independent reviewer for a clinical trial: BMS