In this session filmed at the 16th International Workshop on Multiple Myeloma (iwMyeloma) held in Madrid, Spain, Elena Zamagni, MD, PhD, University of Bologna, Bologna, Italy, Nizar Bahlis, MD, University of Calgary, Calgary, Canada, Enrique Ocio, MD, PhD, Marqués de Valdecilla University Hospital, Santander, Spain, and Carlos Fernández de Larrea, MD, PhD, University of Barcelona, Barcelona, Spain, explore novel therapeutic strategies for multiple myeloma. They comment on strategies to target multiple antigens with CAR-T therapy, the place of cereblon E3 ligase modulators (CELMoDs) in the treatment of multiple myeloma, and the efficacy of modakafusp alfa. The experts finish by highlighting new targetable pathways in myeloma and compare the use of MRI and PET/CT imaging in clinical practice and in clinical trials.