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EHA 2026 | Insights into the evolving treatment landscape for MPNs: current state and future directions

Ruben Mesa, MD, Levine Cancer Institute, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston Salem, NC, shares insights into the current state and future directions of myeloproliferative neoplasms (MPNs) treatment. Dr Mesa highlights the benefits of single-agent JAK inhibitors and notes that upcoming developments include more active or specific inhibitors targeting driver mutations, such as calreticulin and JAK2 inhibitors, as well as new mechanisms of action and additional modifiers, such as hepcidin mimetics and inhibitors. This interview took place at the 31st Congress of the European Hematology Association (EHA) in Stockholm, Sweden.

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