Carlos Fernandez de Larrea, MD, PhD, University of Barcelona, Barcelona, Spain, discusses the challenges associated with relapse after BCMA-targeted therapy with CAR-Ts, antibody-drug conjugates (ADCs) or bispecific antibodies, highlighting the potential of targeting other antigens in patients with multiple myeloma. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.