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ASH 2021 | The relationship between chromosome 1 abnormalities and poor prognosis in multiple myeloma

Chromosome 1 (chr1) copy number abnormalities and structural variants are associated with poor prognosis in patients with multiple myeloma. Patrick Blaney, MS, Perlmutter Cancer Center, NYU Langone Health, New York, NY, describes the design and main findings of a study investigating the relationship between gene deregulation and the chromatin structure of chr1. Using a multiomic mapping approach, the study identified seven hotspots of deletion and nine hotspots of gain occurring on chr1. Although most of these regions overlap with known candidate driver genes, there were also other genes associated with that region that were overexpressed, suggesting that more than one gene causes the disease phenotype. In addition, epigenetic analysis highlighted significant epigenetic alterations across Chr1. According to Mr Blaney, there should be more specificity when defining Chr1 abnormalities as most patients harbour several hotspots of gain or deletion. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.