Saad Usmani, MD, MBBS, MBA, of the Levine Cancer Institute and Atrium Health in Charlotte, NC, shares an update on a Phase I trial (NCT04557098) of teclistamab, a B-cell maturation antigen (BCMA) and CD3-targeting bispecific antibody, for the treatment of relapsed/refractory multiple myeloma. Teclistamab is currently being trialled in a dose-escalation study (NCT03145181) with both subcutaneous and intravenous delivery. Cytokine release syndrome (CRS) has been observed in 55% of patients overall, and in 64% of patients receiving the recommended Phase II dose delivered subcutaneously. All CRS was grade one or two. The overall response rate for the subcutaneous population was 73%. This interview took place during the 47th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT) 2021.