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IMS 2023 | Session highlights: managing the aging population in myeloma & promising treatment options

Paul Richardson, MD, Dana-Farber Cancer Institute, Boston, MA, gives an overview of a session held at this year’s meeting which focused on treating elderly or frail patients with relapsed/refractory multiple myeloma (RRMM), starting with the role of next-generation antibodies such as isatuximab and elotuzumab. Dr Richardson also highlights the encouraging outcomes observed with the combination of pomalidomide and bortezomib, as well as antibody-drug conjugates (ADCs) such as belantamab mafodotin. Following this, Dr Richardson discusses the mechanism of action of other novel therapeutics, including melflufen, a peptide-drug conjugate, selinexor, an XPO1 inhibitor, and the novel CELMoDs iberdomide and mezigdomide. This interview took place at the 20th International Myeloma Society (IMS) Annual Meeting, held in Athens, Greece.

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Consulting: Oncopeptides, Celgene/BMS, Karyopharm, Sanofi, GSK
Research grant: Oncopeptides, Celgene/BMS, Karopharm, Takeda