In this exciting discussion, the experts explore genomics in 2022, highlighting the questions raised by immunotherapy. Specifically discussed is the impact of genomics on the success of immunotherapies in mouse models, how risk stratification may be changed with the advent of immuno-oncology (I-O), and whether dormant cells are susceptible to apoptosis. Gareth Morgan, MD, PhD, FRCP, FRCPath of NYU Langone, New York City, NY chairs this session with Francesco Maura, MD of Sylvester Comprehensive Cancer Center, Miami, FL and Leo Rasche, MD of University of Würzburg, Würzburg, Germany. This discussion took place at The International Workshop on Myeloma 2022 held in Scottsdale, AZ.