Xavier Leleu, MD, MSc, PhD , Poitiers University Hospital, Poitiers, France, shares some insights into how approaches to clinical trials and treatment in multiple myeloma should be changed, drawing focus on the importance of novel immunotherapeutic agents. Prof. Leleu highlights the controversies surrounding this topic and shares some opinions on how treatment and clinical trial design may be improved. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.