Elena Zamagni, MD, PhD, University of Bologna, Bologna, Italy, briefly discusses how to choose the best imaging technique in multiple myeloma, which depends on many factors, including availability of resources, national guidelines, and expertise. Dr Zamagni also mentions the benefit of using PET and MRI, as well as the importance of ensuring that the same imaging technique is used at diagnosis and after treatment. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.