In this video, Zinaida Good, PhD, Stanford University, Stanford, CA, discusses reverse fate mapping of CAR-T cells in patients with large B-cell lymphoma and the importance of understanding how CAR-T cells change on the clonal level. Dr Good explains that because CAR-T therapy is extremely successful in large B-cell lymphoma, it is important to further analyze gene expression in CAR-T cells and see how this information can help researchers better understand which clones are likely to be more successful during treatment. This interview took place at the American Association for Cancer Research Annual Meeting in New Orleans, LA.