Zinaida Good, PhD, Stanford University, Stanford, CA, comments on the findings of using a lineage tracing approach to define responding CAR T-cells in patients with large B-cell lymphoma (LBCL). Identifying which cell populations expand during manufacturing and mediate therapeutic efficacy may allow for a greater ability to manufacture CAR T-cells that will improve patient outcomes. Dr Good also briefly outlines the impact of the presence of regulatory T-cells (Tregs). This interview took place at the American Association for Cancer Research (AACR) Annual Meeting 2024 in San Diego, CA.
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