Xavier Leleu, MD, PhD, Poitiers University Hospital, Poitiers, France, shares some results from the IFM 2014-01 trial, evaluating the safety and efficacy of pomalidomide, dexamethasone and ixazomib for the treatment of patients with high-risk, relapsed/refractory (R/R) myeloma. Prof. Leleu first provides some background information on the use of combination therapy in myeloma, and then highlights the safety and efficacy of this regimen and results obtained in this trial. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.