Saad Usmani, MD, FACP, Levine Cancer Institute, Charlotte, NC, is joined by Ajai Chari, MD, PhD, Mount Sinai Medical Center, New York, NY and Niels van de Donk, MD, PhD, VU University Medical Center, Amsterdam, at the International Myeloma Workshop (IMW) 2019, held in Boston, MA. The speakers discuss different modalities of immunotherapy developed in myeloma, including monoclonal antibodies, myeloma microenvironment and immune signalling.