ASH 2023 | The effect of dose reduction of talquetamab in patients with R/R MM: results from MonumenTAL-1
Ajai Chari, MD, UCSF, San Francisco, CA, discusses the outcomes of talquetamab dose modification in a group of patients with relapsed/refractory (R/R) multiple myeloma (MM) enrolled in the MonumenTAL-1 trial (NCT04634552). Talquetamab elicits some on-target off-tumor effects in many patients, with unique side effects such as dysgeusia and nail- or skin-related adverse events (AEs). Reducing the dosing intensity was not found to compromise the efficacy of the treatment in these patients, and some improvement in treatment-related AEs was observed. Additionally, a unique finding was made, as the occurrence of AEs in the first three months of treatment was associated with a 20% higher likelihood of responding to the drug. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Advisory Board: Glaxo Smith Kline, AbbVie, Seattle Genetics, Amgen, BMS, Janssen, Sanofi, Shattuck Labs, Genentech, Karyopharm, Secura Bio
Consultancy: Millenium/Takeda, Amgen, BMS, Janssen, Antengene, Secura Bio
Research Funding: Millenium/Takeda, Seattle Genetics, Amgen, BMS, Janssen
