ASH 2022 | MonumenTAL-1 update: talquetamab in R/R multiple myeloma
Ajai Chari, MD, PhD, Mount Sinai School of Medicine, New York City, NY, discusses updates from the Phase I/II MonumenTAL-1 trial (NCT03399799/NCT04634552) assessing talquetamab in patients with relapsed/refractory (R/R) multiple myeloma. Whilst the study reported promising response rates in each of the different doses tested, Dr Chari notes that patients experienced unusual off-target toxicities due to GPRC5D expression in normal tissues. Nevertheless, these adverse events were low grade and suggest talquetamab as a good candidate for combination therapies. This interview took place at the 64th ASH Annual Meeting and Exposition Congress held in New Orleans, LA.
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