Saad Usmani, MD, MBA, FACP, Memorial Sloan Kettering Cancer Center, New York, NY, gives an overview of ongoing trials evaluating frontline therapies in patients with multiple myeloma who are transplant eligible. Multiple trials are currently comparing triplet versus quadruplet induction therapy followed by post-transplant consolidation and maintenance with daratumumab and lenalidomide versus lenalidomide alone. Dr Usmani notably mentions CARTITUDE-6 (NCT05257083) which compares autologous stem cell transplantation vs CAR-T therapy with ciltacabtagene autoleucel (cilta-cel) following quadruplet induction therapy. This interview took place at the 19th International Myeloma Society Meeting (IMS) held in Los Angeles, CA.
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