Karthik Ramasamy, MBBS, MRCP, FRCPath, PhD from Oxford University Hospitals NHS Foundation Trust, Oxford, UK provides an overview of three talks on the management of multiple myeloma (MM) presented at the 2016 Annual Meeting of the British Society of Haematology (BSH) and International Society of Hematology (ISH), held in Glasgow, Scotland. The first talk was on smouldering myeloma and the group of patients who are at higher risk of progressing. The second talk discussed the genetics of myeloma and the needs of the so-called high-risk myeloma group. The third talk discussed elderly myeloma patients who form up to 50% of myeloma patients in the United Kingdom. Dr Ramasamy discusses the need to understand their frailty at the outset and then class them into different groups.