In this video, Karthik Ramasamy, MBBS, MRCP, FRCPath, PhD, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, discusses the challenges brought about by the COVID-19 pandemic on myeloma patients and treating clinicians. Dr Ramasamy highlights how vaccination has improved patient outcome, and goes on to discuss the PREPARE study, which is investigating antibody responses and T-cell responses in myeloma patients who have been vaccinated. Dr Ramasamy then discusses how access to other therapies and behavioral measures play an important role in continuing to keep patients safe. This interview took place at the 62nd Annual Scientific Meeting of the British Society for Haematology (BSH) 2022, in Manchester, UK.