Heinz Ludwig, MD, of the Wilhelminen Cancer Research Institute, Vienna, Austria highlights the techniques that we should use to detect and monitor infections in patients with myeloma. Respiratory-tract infections are common and can progress to pneumonia. Sometimes patients may feel weak and fatigued, and the underlying cause for this is very often due to infection, which must be investigated. Antibody testing is not recommended in myeloma patients, as their antibody formation is impaired and results may come out negative. However, PCR technologies are a common method to confirm which virus is causing infection. Multiplex PCR systems are being developed which will enable the detection of different viruses with one test. Recorded at the 2017 European Multiple Myeloma Academy (EMMA) in Vienna, Austria. This program was sponsored by Celgene through an unrestricted educational grant to Video Journal of Hematological Oncology.