Elena Zamagni, MD, PhD, University of Bologna, Bologna, Italy, discusses the use of imaging techniques for patients with high-risk multiple myeloma, emphasizing the importance of using functional imaging in cases of relapsed disease. Dr Zamagni also explains the need to evaluate alternative treatment options for high-risk patients and the role of imaging in this process. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.