Thomas Kipps, MD, PhD, from University of California San Diego, San Diego, CA, Barbara Eichhorst, MD, from University Hospital Cologne, Cologne, Germany, and Arnon Kater, MD, PhD, from the University of Amsterdam, Amsterdam, The Netherlands, discuss the highlights of the 18th International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Biennial Meeting, held in Edinburgh, UK. The speakers discuss new insights into the biology of chronic lymphocytic leukemia (CLL) and their use in patient stratification and the development of treatment algorithms.