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ERIC CLL 2026 | Continuous acalabrutinib versus acalabrutinib plus venetoclax in del(17p) or TP53-mutated CLL
Marta Coscia, MD, PhD, University of Insubria, Varese, Italy, discusses the treatment approach for patients with chronic lymphocytic leukemia (CLL) with a del(17p) or a TP53 mutation. Prof. Coscia notes that the AMPLIFY trial (NCT03836261), which supported approval of the acalabrutinib-venetoclax combination, excluded patients with TP53 alterations; therefore, continuous treatment with a BTK inhibitor remains the preferred option. This interview took place at the 2026 ERIC International Meeting in Barcelona, Spain.
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