In this video, Karthik Ramasamy, MBBS, MRCP, FRCPath, PhD, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, discusses the challenges associated with treating patients with relapsed/refractory (R/R) myeloma. Dr Ramasamy first discusses the psychological burden of relapsed disease, and then mentions the promise of novel combination therapies in improving treatment options for these patients. Following this, Dr Ramasamy explains the need to improve access to BCMA-targeted therapies and the excitement surrounding the future use of chimeric antigen receptor T-cell (CAR-T) therapy in patients who are triple-class refractory. This interview took place at the 62nd Annual Scientific Meeting of the British Society for Haematology (BSH) 2022, in Manchester, UK.