Noemí Puig, MD, PhD, University Hospital Salamanca, Salamanca, Spain, shares an update on the Phase III randomized GEM-CLARIDEX trial (NCT02575144) investigating lenalidomide and dexamethasone with and without clarithromycin in patients with newly diagnosed, previously untreated multiple myeloma. 286 patients patients with multiple myeloma were treated in the trial. At a median follow-up of 19 months, no significant differences in the median progression-free survival (PFS) were observed, despite a higher complete response (CR) rate in patients receiving additional clarithromycin. Dr Puig gives an overview of the key findings from the trial, in particular discussing the safety profile of clarithromycin plus lenalidomide and dexamethasone. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.