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IMS 2023 | BMS-986393, a novel anti-GPRC5D CAR-T cell therapy, in multiple myeloma

Targeting GPRC5D has resulted in novel therapies for multiple myeloma. Omar Nadeem, MD, Dana-Farber Cancer Institute, Boston, MA, provides an overview of results from a Phase I study (NCT04674813) of BMS-986393 (CC-95266), a GPRC5D-targeted CAR-T cell therapy for relapsed/refractory (R/R) multiple myeloma. 67 heavily pre-treated patients were enrolled and demonstrated promising efficacy. The incidence of adverse events (AEs) such as cytokine release syndrome (CRS) was similar to other CAR-T cell therapies. This interview took place at the 20th International Myeloma Society (IMS) Annual Meeting, held in Athens, Greece.

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Advisory boards: Janssen, BMS, Takeda, Sanofi, GPCR Therapeutics, GSK