Ola Landgren, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, outlines a study investigating the onset of multiple myeloma (MM). This analysis investigates the early stages of myelomagenesis, where the acquisition of the first key driver mutations precedes diagnosis by decades. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.