Lars Bullinger, MD, from the University Hospital of Ulm, Ulm, Germany discusses the advantages of next-generation sequencing (NGS) in comparison to conventional Sanger sequencing, noting that NGS has saved researchers an abundance of time and money. In addition, it has allowed deeper sequencing in that subclones of mutations can be detected, which have previously been undetectable. He mentions that it is important to detect these subclones in patients with diseases such as acute myeloid leukemia, as these patients may represent those who are treatment-resistant or responsive. This interview was filmed at the European Hematology Association (EHA) 2017 Annual Congress in Madrid, Spain.