Lars Bullinger, MD, Charité University of Medicine, Berlin, Germany, discusses the minimal and optimal gene panel in acute myeloid leukemia (AML). The minimal gene panel should include the six gene markers in the current European LeukemiaNet (ELN) guidelines (NPM1, CEBPA, RUNX1, FLT3, TP53, ASXL1) as well as the IDH1 and IDH2 gene mutations. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).