Lars Bullinger, MD, of Charité University of Medicine, Berlin, Germany, discusses progress in immuno-oncology for the treatment of acute myeloid leukemia (AML). Specifically discussed is the identification of a new checkpoint, CD47, which is expressed on macrophages within the tumor microenvironment as well as compound CAR-T cells and BiTEs presented at EHA 2020. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).