In this inaugural episode of Myeloid Monthly, host Amer Zeidan, MBBS, MHS, Yale University and Yale Cancer Center, New Haven, CT, is joined by hematopathology experts Sanam Loghavi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Robert Hasserjian, MD, Massachusetts General Hospital, Boston, MA, reporting from the Classification Advancement Meeting (CAM) in Chicago, IL. This is a landmark effort to harmonize the two competing myeloid malignancy classification systems, the WHO and ICC, which diverged in 2022. The experts break down why accurate disease classification matters for patient care, clinical trial enrollment, and drug development, and explore how the field has evolved from morphology-based diagnosis toward molecularly defined disease entities across myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and MDS/myeloproliferative neoplasm (MPN) overlap syndromes. The CAM represents years of expert working group discussions aimed at producing unified recommendations that will inform the next official WHO classification. This webinar took place virtually.
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