Immunotherapy for multiple myeloma: current research avenues

Shaji Kumar, MD from the Mayo Clinic, Rochester, MN discusses the current research on immunotherapy in multiple myeloma (MM). The biggest advance so far is daratumumab according to Dr Kumar. Daratumumab is a monoclonal antibody targeting CD38 and its has been to shown to have high efficacy as a single agent and in combination with lenalidomide and bortezomib. Elotuzumab, which targets SLAMF7, has also been shown to be active in combination with bortezomib and pomalidomide. Dr Kumar further discusses CAR T-cell therapy, which is in early clinical development and has shown efficacy in leukemia with some reports that it might also be effective in myeloma. Finally, he talks about vaccination studies and checkpoint inhibitors.
Recorded at the European Hematology Association (EHA) 2016 Annual Congress in Copenhagen, Denmark.

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