Luciano Costa, MD, PhD, UAB School of Medicine, Birmingham, AL, provides an overview of using minimal residual disease (MRD) to guide myeloma treatment. Despite initial concerns using MRD-guided therapy, MRD is a strong predictor of risk and outcomes, where MRD status can determine duration of therapy. Dr Costa additionally highlights potential clinical trials that utilizes the MRD status of patients to escalate or deescalate therapy. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.