ASH 2023 | Risk factors for venous thromboembolic events in pregnant patients with SCD

Lydia Pecker, MD, Johns Hopkins University School of Medicine, Baltimore, MD, discusses a retrospective study which investigated the risk factors for venous thromboembolic events (VTE) in pregnant patients with sickle cell disease (SCD). Of the 290 pregnancies included in the analysis, 7% had a reported VTE (deep vein thrombosis and/or pulmonary embolism) and several risk factors for a VTE during gestation were markers of disease severity, including history of VTE, hydroxyurea use, intrapartum painful events, and acute coronary syndrome. As thrombosis was associated with premature delivery and increased C-section rates, as well as the rate of VTE exceeding the American Society of Hematology threshold for initiating anticoagulation prophylaxis, it is necessary to address the unmet need for specific pregnancy guidelines in individuals with SCD. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.

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