ASH 2018 | Renal response to carfilzomib vs. bortezomib in R/R MM in the real world

Noopur Raje

In clinical trials, the proteasome inhibitors carfilzomib (K) and bortezomib (V) have demonstrated efficacy in relapsed/refractory multiple myeloma (MM) patients with renal impairment (RI). Noopur Raje, MD, of Massachusetts General Hospital, Boston, MA, introduces a study aiming to tackle the lack of real world data in R/R MM patients treated with K plus dexamethasone (Kd) and V plus dexamethasone (Vd) in clinical practice. Speaking from the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition in San Diego, CA, Dr Raje reveals that patients treated with Kd had higher rates of overall and complete renal response, and were more likely to have a renal response, compared with those treated with Vd.

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