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ASH 2020 | Belantamab mafodotin in myeloma: advantages and disadvantages

Rakesh Popat, MBBS, MRCP, FRCPath, PhD, University College London Hospitals NHS Foundation Trust, London, UK, discusses the mode of action of the BCMA-targeting antibody-drug conjugate (ADC) belantamab mafodotin (belamaf) in patients with relapsed/refractory multiple myeloma. The DREAMM-2 study (NCT03525678) has shown good overall response rates, but its use was associated with notable adverse events, including thrombocytopenia and corneal defects. Dr Popat goes on to highlight that with ophthalmology collaboration, belamaf can be managed effectively and will be added to standard of care regimens in the near future. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.

Disclosures

Honoraria: Takeda, Abbvie, GSK
Consultancy: BMS, Janssen, GSK

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