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EHA 2026 | Targeting mutant CALR in MF and ET: the therapeutic potential of INCA33989

John Mascarenhas, MD, Icahn School of Medicine at Mount Sinai, New York, NY, comments on the therapeutic potential of INCA33989, a CALR-specific monoclonal antibody for the treatment of myelofibrosis (MF) and essential thrombocythemia (ET). Dr Mascarenhas highlights promising preclinical and clinical results, with significant effects in reducing mutant CALR-bearing hematopoietic stem and progenitor cells. This interview took place at the 31st Congress of the European Hematology Association (EHA) in Stockholm, Sweden.

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