Measurable residual disease (MRD) is increasingly being used as a predictor of outcomes in multiple myeloma (MM), which makes its accurate detetction a key step in the management of the disease. Here, Hiroyuki Takamatsu, MD, PhD, of Kanazawa University, Kanazawa, Japan, discusses a study comparing the use of 8-color flow cytometry and next-generation sequencing for the detection of MRD in the autografts of MM patients. This video was recorded at the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition in San Diego, CA.