Luciano Costa, MD, PhD, UAB School of Medicine, Birmingham, AL, shares his highlights from ASH 2020 in multiple myeloma, picking out BCMA-targeted approaches including chimeric antigen receptor (CAR) T-cell therapies, antibody-drug conjugates and bispecific T-cell engagers. Dr Costa also discusses three trials in relapsed/refractory multiple myeloma, including a Phase I study (NCT03399799) investigating talquetamab, a bispecific antibody that binds GPRC5D and CD3, the Phase I GO39775 trial (NCT03275103) of the bispecific T-cell engager BFCR4350A, and updated results from a Phase 1 trial (NCT03145181) of the BCMA-targeting bispecific antibody therapy teclistamab. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.