Noelle Frey, MD, University of Pennsylvania, Philadelphia, PA, is joined by Daniel Lee, MD, University of Virginia, Charlottesville, VA, and Bianca Santomasso, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, in a roundtable discussion at the 1st International Workshop on CAR-T, held in Miami, FL. The speakers talk about toxicities in those treated with CAR T-cell therapy, with a focus on cytokine release syndrome (CRS) and neurotoxicity. They discuss the consensus grading scale, best management and the potential for consensus guidelines moving forwards.