From the 1st International Workshop on CAR-T (iwCAR-T), held in Miami, FL, John Gribben, MD, DSc, FRCPath, FMed Sci, Barts Cancer Institute, London, UK, Noelle Frey, MD, University of Pennsylvania, Philadelphia, PA, and David Maloney, MD, PhD, Fred Hutchinson Cancer Research Center, Seattle, WA, discuss the current updates in CAR-T toxicity. The speakers share their thoughts on managing CAR T-cell therapy-related toxicity and discuss the consensus grading scale for CRS and neurotoxicity.