In this session, Matthew Frigault, MD, Harvard Medical School, Boston, MA, and Bianca Santomasso, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, discuss the prophylaxis and management of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) following CAR-T therapy, commenting on blocking IL-6 and IL-1, the use of steroids, and doing prospective studies on prophylactic interventions. This discussion took place at the 5th International Workshop on CAR-T (iwCAR-T) 2023 held in Scottsdale, AZ.
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