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IMS 2023 | Metabolic reprogramming confers resistance to lenalidomide in multiple myeloma

Wee Joo Chng, MB ChB, MRCP, MRCPath, PhD, National University of Singapore, Singapore, discusses the role of NSD2, a histone methyltransferase, in resistance to lenalidomide in patients with multiple myeloma. Patients with a t(4;14) translocation tend to have high-risk multiple myeloma, leading to overexpression of NSD2 and metabolic dysregulation. Modulating the metabolic pathway may subsequently enhance sensitivity to existing treatments such as lenalidomide and pomalidomide. This interview took place at the 20th International Myeloma Society (IMS) Annual Meeting, held in Athens, Greece.

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