Jill Corre, PharmD, PhD, The Cancer University Institute of Toulouse Oncopole (IUCT), Toulouse, France, briefly discusses subclonal evolution in multiple myeloma, and the importance of identifying high-risk cytogenetic markers at diagnosis. Dr Corre explains how gain of chromosome 1q (+1q) is better detected by single-cell analysis and the importance of identifying high-risk markers such as (+1q) or del(17p) at an earlier stage to improve patient prognosis. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.