Eunice S. Wang, MD, Roswell Park Comprehensive Cancer Center, Buffalo, NY, describes early data using an Actinium immunoconjugate to cytoreduce patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) prior to allogeneic stem cell transplantation (alloSCT). In this advanced setting, this novel agent is able to successfully bridge patients to alloSCT and may represent an effective pre-conditioning regimen. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.