Matthew J. Frigault, MD, Harvard Medical School, Boston, MA, discusses the safety and efficacy results of a Phase I study of CART-ddBCMA, an autologous anti-BCMA CAR-T cell therapy that utilizes a novel, synthetic binding domain, called a D-Domain, instead of a typical scFv binder, in patients with relapsed/refractory (R/R) multiple myeloma. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.